![]() Esperanza, Díaz, L., Lucas, R., Gómez-Martínez, S., Bastida, S., Marcos, A., & Sánchez-Muniz, F. Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia-reoxygenation. Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: Scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Hydroxytyrosol: From laboratory investigations to future clinical trials. L., Sanchez-Rovira, P., & Ramirez-Tortosa, M. ![]() Journal of Agriculture and Food Chemistry, 52, 267–273. Toward a high yield recovery of antioxidants and purified hydroxytyrosol from olive mill wastewaters. ![]() Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. European Journal of Pharmacology, 718, 213–218.įriedewal, W. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infracted rats. Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Chemical Biological Interaction, 180, 421–432. Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats. Hamden, K., Allouche, N., Damak, M., & Elfeki, A. Annali dell’Istituto Superiore di Sanità, 43, 375. Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: A review. De, La Torre, R., Farre-Albaladejo, M., Khymenetz, O., Marrugat, J., & Covas, M. Journal of Pharmacolgical Toxicology, 6, 1–17.įito, M. Isoproterenol induced myocardial infarction: Protective role of natural products. Upaganlawar, A., Gandhi, H., & Balaraman, R. Proteomics-Clinical Applications, 2, 845–861. Mitochondria: A mirror into cellular dysfunction in heart disease. Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure. Overall, these findings demonstrated that HT exerted a potent cardioprotective effect against isoproterenol-induced myocardial infarction.Īronow, W. However, pre- and co-treatment with HT (2 and 5 mg/kg) improved the myocardium injury, restored the hemodynamic function and inhibited the ACE activity that prevent cardiac hypertrophy and remodeling. Else, a disturbance in lipids profile and significant increase in lipase and angiotensin-converting enzyme (ACE) activities and heart weight ratio were observed in isoproterenol group. Moreover, cardiac injury markers (creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase) underwent a notable rise in serum of infarcted animals. Isoproterenol exhibited changes in ECG pattern, including significant ST-segment elevation and increase in the serum troponin-T level by 317 % as compared to control rats. On 8th day, electrocardiographic (ECG) pattern, gravimetric and biochemical parameters were assessed. Myocardial infarction in rats was induced subcutaneously by isoproterenol (100 mg/kg, s.c.) at an interval of 24 h on 6th and 7th day. Male rats were randomly divided into four groups, control, isoproterenol (Isop) and pretreated animals with HT in two different doses (2 and 5 mg/kg) orally for 7 days and intoxicated with isoproterenol (Isop + HT1) and (Isop + HT2) groups. ![]() The present study aimed to investigate the cardioprotective effect of hydroxytyrosol (HT) against isoproterenol-induced myocardial infarction in rats.
0 Comments
Leave a Reply. |